AGAP2-AS1 100130776 AGAP2 antisense RNA 112. 58120023. 58122139 +. -0,112. 34,114. 0,176. 71,687. -8,46 sig. AGAP3. 116988 ArfGAP with GTPase

2017-02-16 · AGAP2-AS1 was highly expressed in the GC tissues and cell lines, and patients with higher AGAP2-AS1 expression had a poorer prognosis and shorter overall survival. Furthermore, knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo.

AGAP2- 25 Sep 2020 The current study aimed to elucidate the role of lncRNA AGAP2-AS1/miR-195-5p/ PDZ and LIM domain 5 (PDLIM5) in prostate cancer 5 Mar 2021 AGAP2-AS1 (AGAP2 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with AGAP2-AS1 include 18 Sep 2020 The lncRNA AGAP2 antisense RNA 1 (AGAP2-AS1) is Keywords: LncRNA, AGAP2-AS1, papillary thyroid cancer, miR-424-5p, MMP2. with three genes (CTBP1-AS2, OTUD6B-AS1, and AGAP2-AS1) exceeding the study-wide Bonferroni- corrected P-value (PBonf < 0.0023, Pcombined ¼ 1.1 Â OTUD6B-AS1 and AGAP2-AS1) exceeding the study-wide Bonferroni-corrected ρ-value. 96. (PBonf<0.0023, Pcombined = 1.1x10-9, 1.4x10-8, 1.7x10-6, 2, AGAP2-AS1 (AGAP2 Antisense RNA 1), miR-16-5p, ANXA11, 31088485. 3, AK054386, miR-199, None specified, 31827704. 4, ANRIL (CDKN2B antisense 9 Mar 2017 Additional file 1: Table S1. of Long noncoding AGAP2-AS1 is activated by SP1 and promotes cell proliferation and invasion in gastric cancer.

Agap2-as1

In addition, we demonstrated that AGAP2-AS1 promotes the proliferation of CCA. AGAP2-AS1 and miR-497 in Ago2 complex, indicating that AGAP2-AS1 could directly bind to miR-497 (Figure 5D). These results suggest that AGAP2-AS1 interacts with miR-497. FGFR1 was targeted by miR-497 in CRC cells Furthermore, dual luciferase reporter assay showed that overexpression of AGAP2-AS1 blocked the inhibition Symbol: AGAP2-AS1: Name: AGAP2 antisense RNA 1: Type: other: Synonyms: AGAP2 antisense RNA 1, AGAP2-AS1, LOC100130776, PNS, PUNISHER: Species: Human (AGAP2-AS1 EG Long non-coding RNA (lncRNA) AGAP2-AS1 acts as an oncogene in several types of cancers. However, the role and mechanism of AGAP2-AS1 in papillary thyroid carcinoma (PTC) remain unclear. Thus, in this study, we aimed to explore the role of AGAP2-AS1 in PTC. Our results showed that AGAP2-AS1 was significantly upregulated in PTC tissues.

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>tr|H2N5H1|H2N5H1_PONAB Uncharacterized protein OS=Pongo abelii GN=RUSC1-AS1 PE=4 SV=1

(PBonf<0.0023, Pcombined = 1.1x10-9, 1.4x10-8, 1.7x10-6, 2, AGAP2-AS1 (AGAP2 Antisense RNA 1), miR-16-5p, ANXA11, 31088485. 3, AK054386, miR-199, None specified, 31827704.

Besides, lncRNA AGAP2-AS1 could bind to miR-195-5p which targeted PDLIM5 and subsequently downregulated its expression, ultimately impeding the progression of prostate cancer. Additionally, lncRNA AGAP2-AS1 inhibition led to an up-regulated expression of miR-195-5p and down-regulated PDLIM5 expression, resulting in delayed tumor growth in vivo. Mechanistically, AGAP2-AS1 is associated with HuR, and the AGAP2-AS1–HuR complex could directly bind to the CPT1, increasing its expression via improving RNA stability. In addition, AGAP2-AS1 AGAP2-AS1 has 521 functional associations with biological entities spanning 3 categories (chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets. Click the + buttons to view associations for AGAP2-AS1 from the datasets below.
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13 In AGAP2-AS1 promotes CCA cell proliferation in vitroandvivo.(A-B)CCK-8 assay was performed to determine the proliferation of HUCCT1 and RBE cells with si-AGAP2-AS1 1, 2, pcDNA-AGAP2-AS1, or the In summary, AGAP2‐AS1 is a prognostic biomarker for patients with GBM, and functions as an oncogenic lncRNA to modulate GBM cell proliferation, apoptosis, migration, and invasion, which suggests that AGAP2‐AS1 is potential therapeutic target for GBM. Expression of AGAP2-AS1 in colon tissue.

However, the expression pattern and molecular mechanism of AGAP2-AS1 in gastric cancer (GC) have not been characterized. AGAP2-AS1 was demonstrated as an oncogene in several cancers, including glioblastoma (GBM).
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HGNC data for AGAP2-AS1. Approved symbol. AGAP2-AS1. Approved name. AGAP2 antisense RNA 1. Locus type. RNA, long non-coding. HGNC ID. HGNC:

AGAP2-AS1 is upregulated in lung cancer and can interact with EZH2 and LSD1 to suppress the expression of LATS2 and KLF2, thereby promoting tumor growth. 11 In gastric cancer, SP1 activates AGAP2-AS1 to increase cancer cell migration and proliferation.

AGAP2-AS1 demonstrated higher expression in tumor tissues compared with normal tissues (P<0.001; Fig. 1A). Additionally, the expression of AGAP2-AS1 was analyzed in 72 pairs of ccRCC tissues and non-cancerous adjacent tissues using Wilcoxon singed-rank test.

(A) Differentially expressed lncRNAs between ovarian cancer (OC) tissues (n=267) and ovarian borderline tumors (n=18). (B) AGAP2-AS1 decreased in OC tissues compared to ovarian borderline tumors (P < 0.05, Student's t-test). AGAP2-AS1 demonstrated higher expression in tumor tissues compared with normal tissues (P<0.001; Fig. 1A). Additionally, the expression of AGAP2-AS1 was analyzed in 72 pairs of ccRCC tissues and non-cancerous adjacent tissues using Wilcoxon singed-rank test. Title: AGAP2-AS1 regulates AGAP2 mRNA levels Abstract: AGAP2-AS1 is an antisense lncRNA situated in the 3’ end of AGAP2. It is becoming now more widely accepted that 3’ antisense lncRNAs can modify the expression of their gene counterparts and we demonstrate here that this is the case as well for the tandem AGAP2 – AGAP2-AS1.

The function of AGAP2-AS1-miR-15a/b-5p-HDGF axis was confirmed by performing rescue assays.